By Gustavo Maroni
Drosophila, the typical fruit fly, is the main widely studied of all organisms from the perspective of genetics and cytology. This atlas summarizes what's identified in regards to the nearly a hundred Drosophila genes for which the entire nucleotide series is understood. each one access features a description of the gene's molecular association and expression, the entire nucleotide and amino acid sequences, maps of fascinating buildings, highlights of sensible beneficial properties and promoter regulatory areas, and chosen references to the first literature. A separate part of the atlas considers varied points of gene association as they take place within the Drosophila genome. issues lined contain measurement correlations between numerous genetic parts, splicing signs, translation initiation indications, and codon bias. The paintings represents a brand new milestone in summarizing present info and making it simply obtainable to geneticists and biologists.
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Extra resources for An Atlas of Drosophila Genes: Sequences and Molecular Features
42 AN ATLAS OF DROSOPHILA GENES Adh-dup The putative 5' end of this gene is positioned very near the 3' end of Adh and probably originated as a duplication (Adh Sequence; Fig. 1). It is present in other Drosophila species (including those of the pseudoobscura group). The amino acid sequence of the two genes is approximately 38% identical, and the coding region introns are similarly positioned. The nature or function of the product is not known (Schaeffer and Aquadro 1987; Kreitman and Hudson 1991).
The 5' and 3' ends of AmyB were deduced from sequence similarity to AmyA (Okuyama and Yamazaki 1988; D. A. Mickey, personal communication) (AmyA and AmyB Sequence). References Benkel, B. F. and Hickey, D. A. (1987). A Drosophila gene is subject to glucose repression. Proc. Natl Acad. Sci. (USA) 84:1337-1339. Boer, P. H. and Hickey, D. A. (1986). The a-amylase gene in Drosophila melanogaster: nucleotide sequence, gene structure and expression motifs. Nucl. Acids Res. 14:8399-8411. Doane, W. , Kolar, M.
Nucleotide sequence of the duplicated Amylase structural genes in Drosophila melanogaster. Proc. Japan Acad. Ser. B 64:274-277. 5 The Andropin and Cecropins Gene Cluster: Anp, CecAl, CecAl, CecB, CecC Chromosomal Location: Map Position: 3R, 99E 3- Products Antibacterial peptides. Structure Sequence analysis suggests that each polypeptide may fold into two amphipathic a-helices separated by a four-amino-acid loop (Samakovlis et al. 1991). By analogy to the better-characterized cecropins of the moth Hyalophora cecropia, processing is predicted to include the removal of the signal peptide and of an additional dipeptide at the N-terminus, and cleavage of the terminal Gly plus amidation at the C-terminus.
An Atlas of Drosophila Genes: Sequences and Molecular Features by Gustavo Maroni