Prof. Antonio Vidal-Puig MD, PhD, FRCP (auth.), Matej's A Systems Biology Approach to Study Metabolic Syndrome PDF

By Prof. Antonio Vidal-Puig MD, PhD, FRCP (auth.), Matej Orešič, Antonio Vidal-Puig (eds.)

ISBN-10: 3319010077

ISBN-13: 9783319010076

ISBN-10: 3319010085

ISBN-13: 9783319010083

The objective of this ebook is to supply the objective viewers, in particular scholars of drugs, Biology, structures Biology and Bioinformatics, in addition to skilled researchers in examine fields correct to metabolic syndrome (MetS) with an outline of the demanding situations and possibilities in structures biology and the way it may be used to take on MetS. particularly, the goals are: (1) to supply an creation to the major organic techniques all in favour of the pathophysiology of MetS; (2) by using particular examples, supply an advent to the most recent applied sciences that use a platforms biology method of learn MetS; and (3) to offer an outline of the mathematical modeling ways for learning MetS.

The in actual fact written chapters by means of best specialists within the box presents certain descriptions an important for the original place of this booklet and its specialise in the applying of structures biology to take on particular pathophysiologically suitable facets of MetS and gives a helpful sensible consultant to this examine community.

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Example text

Intriguingly DNL can be detected not only in hyperinsulinemic condition but also in healthy subjects through a high-carbohydrate meal; acute fructose ingestion increases DNL and postprandial TG levels (Parks et al. 2008). Insulin and glucose both drive DNL, through the respective activation of sterol regulatory element binding proteins (SREBPs) and carbohydrate response element-binding protein (ChREBP), which transcriptionally induce most genes involved in FA synthesis (Browning and Horton 2004).

Thus, a metabolic imbalance of glucose and lipid metabolism may results in hepatic steatosis. On the other hand, insulin is responsible for the maintenance of glucose and lipid homeostasis in the liver, which is its main site of action in addition to adipose tissue and skeletal muscle. A condition of IR determines different pathogenetic effects depending on the metabolic pathway involved, thus a refractory insulin-response leads to increased glucose production in liver, and to activation of the lipid synthesis and dyslipidemia, which can lead to hepatic steatosis.

Thus, a metabolic imbalance of glucose and lipid metabolism may results in hepatic steatosis. On the other hand, insulin is responsible for the maintenance of glucose and lipid homeostasis in the liver, which is its main site of action in addition to adipose tissue and skeletal muscle. A condition of IR determines different pathogenetic effects depending on the metabolic pathway involved, thus a refractory insulin-response leads to increased glucose production in liver, and to activation of the lipid synthesis and dyslipidemia, which can lead to hepatic steatosis.

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A Systems Biology Approach to Study Metabolic Syndrome by Prof. Antonio Vidal-Puig MD, PhD, FRCP (auth.), Matej Orešič, Antonio Vidal-Puig (eds.)


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